|
KMID : 0369820080380020093
|
|
Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 2 p.93 ~ p.98
|
|
|
Anti-Proliferative Effect of Tetraphenylporphine (TPP) as an Iron Chelator on Vascular Smooth Muscle Cells and its Release Profiles from Polymer Coating Layer
|
|
Park Min-Hee
Kang Soo-Yong
Park Hyun-Jeong
Seo Jin-Seon
Park Young-A
Kim Ji-Eun
Kim Yang-Keun
Wang Bae-Gun
Munkhjargal, Odonchimeg
Shim Young-Key
Kho Weon-Gyu
Lee Woo-Kyoung
|
|
|
Abstract
|
|
|
|
The drug-eluting stent (DES) implantation is a widely acceptable treatment for coronary heart disease. It was reported that iron chelator had anti-proliferative effect on human vascular smooth muscle cells (HA-VSMCs). In this study, tetraphenylporphine (TPP) was selected as an iron chelator and drug for DES. MTT assay showed that TPP had antiproliferative effect on HA-VSMCs. TPP and polycaprolactone (PCL) were coated onto stainless steel plate using a spraycoating method. From the surface morphology examination of the coated plate by SEM, smooth polymer coating layer could be observed. The thickness of coating layer could be controlled by changing repeating time of coating. From in vitro release test, sustained release of TPP was observed from plate during two weeks. Thus, TPP as iron chelator can be used as drug for stent coating because of its antiproliferative effect and sustain release profile.
|
|
|
KEYWORD
|
|
|
Drug-eluting stent, Tetraphenylporphine (TPP), Polycaprolactone (PCL), Iron chelator, VSMC
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|